The cytoplasmic C terminus of the β2-adrenergic receptor and several additional G protein-coupled receptors contains a dileucine sequence that is implicated in endosome/lysosome targeting of diverse proteins. or stably expressed in CHO or HEK-293 cells transiently. Nevertheless agonist-induced receptor internalization was markedly impaired in the L339 340 dual mutant and low in the two solitary […]